ABSTRACT
We examined the plasmatic concentrations of quinine in patients with uncomplicated falciparum malaria in an endemic area of the Amazon region in Brazil in a prospective clinical trial, in which a standard three-day course of oral quinine plus doxycycline was used. We measured the quinine in the plasma samples on days 0 and 3by high performance liquid chromatography. The mean concentration of quinine was 6.04 ±2.21 µg/mL in male patients and 5.98 ±1.95 µg/mL in female patients. No significant differences in quinine concentration were observed between these two groups. All samples collected before starting treatment were negative for quinine. This information could help in the development of strategies for the rational use of antimalarial drugs in Brazil.
Subject(s)
Adult , Animals , Female , Humans , Male , Antimalarials/blood , Malaria, Falciparum/blood , Quinine/blood , Antimalarials/therapeutic use , Chromatography, High Pressure Liquid , Drug Monitoring , Drug Therapy, Combination , Doxycycline/therapeutic use , Malaria, Falciparum/drug therapy , Prospective Studies , Quinine/therapeutic useABSTRACT
Objetivo: quantificar os teores de dióxido de enxofre residual em camarão-rosa, consumidos em Belém, no estado do Pará, a fim de verificar se as concentrações presentes encontram-se dentro dos valores recomendados pela legislação vigente. Método: estudo analítico dos teores de enxofre residual em camarões por titulação iodométrica a frio, após prévia dissolução das amostras em meio ácido. Resultados: a concentração média de dióxido de enxofre residual nas amostras deFarfantepenaeus subtilis com exoesqueleto foi 501 ±104 ppm e sem exoesqueleto de 538± 117 ppm. Não se observou diferença estatística signifcativa (p>0,05) entre os teores médios de dióxidode enxofre resídual em função do exoesqueleto. Conclusão: as amostras analisadas apresentaram teores de dióxido de enxofre residual acima do limite máximo recomendado na legislação, isto é, 100 ppm. Os resultados indicam a possibilidade da exposição humana ao dióxido de enxofre viaingestão de camarão-rosa.
Objective: To determine the residual sulphur dioxide in Farfantepenaeus subtilis samples from Belém-Pará, and determine if the levels are in agreement with the official recomendations. Method: Analysis by cold iodometric titration after acid dissolution of samples. Results: The meanconcentration of residual sulphur dioxide in Farfantepenaeus subtilis samples was 501 ±104 ppm. The samples analyzed presented residual sulphur dioxide above the limit recommended and characterize the human exposure to this compound